Description
Product Characteristics:
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Human T cell leukemia virus type 1-binding protein, Liver regeneration-related protein LRRG004, MGC94031, PRO0105, T6BP, Tax1 human T cell leukemia virus type I binding protein 1, Tax1 human T cell leukemia virus type I binding protein, Tax1 binding protein 1, Tax1 binding protein, Tax1-binding protein 1, Tax1-binding protein 1 homolog, TAX1BP1, TAX1BP1 protein, tax1bp1b, TAXB1_HUMAN, TRAF 6 binding protein, TRAF6 binding protein, TRAF6 binding protein T6BP, TRAF6-binding protein, TRAF6-interacting protein, TXBP 151, TXBP151
Target Information: This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]